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Treatment of Murine Leukaemia with Heterologous Antiserum or Cyclophosphamide

Nature volume 232, pages 196–197 (1971)Cite this article

Abstract

WE have compared chemotherapy and immunotherapy in AKR mice injected with a syngeneic tumour, strain BW5147 lymphatic leukaemia. Previous investigations disclosed significant therapeutic benefit from isologous or homologous antiserum against mouse leukaemia1–4 or with antiserum raised against murine tumour viruses5. In contrast, toxicity has been a significant obstacle to the therapeutic use of heterologous antiserum6,7. Reports8–12 of successful use of heterologous antiserum, however, suggested that further study was warranted, and an experiment was designed to compare quantitatively the therapeutic activity of antiserum with conventional chemotherapy.

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  1. Department of Surgery, University of Colorado Medical Center, 4200 E. 9th Avenue, Denver, Colorado, 80220

    GEORGE J. HILL II

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  1. GEORGE J. HILL II
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HILL, G. Treatment of Murine Leukaemia with Heterologous Antiserum or Cyclophosphamide. Nature 232, 196–197 (1971). https://doi.org/10.1038/232196a0

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