Abstract
WHITE blood cells from normal healthy O group people, when suitably tagged with chemicals such as 1-fluoro-2,4-dinitrobenzene (FDNB), can be used as antigens to stimulate the production of antibodies to human leukaemic cells in rabbits and horse1,2. We have shown that chemically tagged normal O group white blood cells can be used successfully to induce a specific autoimmune response to leukaemic cells in human leukaemic patients.
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References
Sahasrabudhe, M. B., Indian J. Cancer, 5, 217 (1968).
Sahasrabudhe, M. B., Prema, S., Madyastha, K. R., Gollerkeri, M. P., and Rao, S. S., Nature, 232, 197 (1971).
Berenbaum, M. C., in Immunity, Cancer and Chemotherapy (edit. by Mihich, E.), 217 (Academic Press, 1967).
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SAHASRABUDHE, M., MADYASTHA, K., PREMA, S. et al. Induction of Specific Autoimmune Response to Leukaemic Cells in Human Leukaemia Patient by Chemically Tagged Normal “O” Group White Blood Cells. Nature 232, 198–199 (1971). https://doi.org/10.1038/232198a0
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DOI: https://doi.org/10.1038/232198a0
