Abstract
BECAUSE of the variability of tissue culture samples, it is often impossible or impractical to measure precisely all the relevant dependent variables under a selected set of conditions. Computer modelling is an attractive technique for studying complicated structures in complex environments, because of the perfect reproducibility of the results and the precision with which all the characteristics (fluxes, internal compositions, potentials) of the tissue are self-consistently determined. The accuracy is of course no better than those input tissue properties to which the answers are most sensitive.
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References
Green, K., Nature, 217, 1074 (1968).
Dorm, A., Maurice, D. M., and Mills, N. L., Arch. Ophthal., 62, 748 (1959).
Green, K., Exp. Eye Res., 6, 79 (1967).
Ehlers, N., and Enhlers, D., Acta Ophthal., 46, 767 (1968).
Donn, A., Miller, S. L., and Mallett, N. M., Arch. Ophthal., 70, 515 (1963).
Katchalsky, A., and Curran, P. F., Nonequilibrium Thermo dynamics in Biophysics (Harvard University Press, Cambridge, 1965).
Maurice, D. M., in Structure of the Eye (edit. by Smelser, G.) (Academic Press, New York, 1961).
Kedem, O., and Katchalsky, A., J. Gen. Physiol., 45, 143 (1961).
Green, K., Exp. Eye Res., 6, 79 (1967).
Edsall, J. T., and Wyman, J., Biophysical Chemistry, 1 (Academic Press, New York, 1958).
Maurice, D. M., in The Eye (edit. by Davson, H.), 1 (Academic Press, New York, 1962).
Trenberth, S. M., and Mishima, S., Invest. Ophthal., 7, 44 (1968).
Rehm, W. S., J. Theoret. Biol., 20, 341 (1968).
Ussing, H. H., Quart. Rev. Biophys., 1, 365 (1969).
Friedman, M. H., Biophys. J., 10, 1013 (1970).
Friedman, M. H., Proc. Austral. Chem. Eng. Conf. (in the press).
Kedem, O., and Katchalsky, A., J. Gen. Physiol., 45, 143 (1961).
Ehlers, N., Danish Med. Bull., 13, 133 (1966).
Maurice, D. M., Exp. Eye Res., 6, 138 (1967).
Trenberth, S. M., and Mishima, S., Invest. Ophthal., 7, 44 (1968).
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FRIEDMAN, M. Application of Computer Experimentation to the Cornea. Nature 233, 553–555 (1971). https://doi.org/10.1038/233553a0
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DOI: https://doi.org/10.1038/233553a0
