Modification of Hyperacute Rejection of Sheep Kidney Heterografts in the Dog using a Trypsin Inhibitor

Abstract

WHEN the species barrier is crossed in organ transplantation, rejection is often hyperacute and immediate. Thus when a sheep kidney is perfused from the dog circulation, the blood flow through the kidney ceases in about 10 min and the transplanted organ increases in weight considerably. Platelet levels and platelet stickiness measured in the sheep renal vein effluent and in the dog circulation reveal marked platelet trapping by the rejected organ. Those platelets that do emerge are not very sticky. The second of a pair of sheep kidneys connected to the same dog circulation after rejection of the first follows a similar pattern of rejection (Tables 1 and 2).