Abstract
SENESCENCE has been viewed as the progressive loss or diminution of the ability of an organism to regulate or maintain obligatory levels of activity of its various enzymes1–8. The primary reason(s) for this age-dependent loss in regulatory capacity is unknown. The study of the biochemical parameters associated with senescence has been hampered by the inability to correlate a decreased functional capacity for the organism with a loss or diminution of functional capacity at the molecular level.
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BAIRD, M., SAMIS, H. & MASSIE, H. Recovery from Zoxazolamine Paralysis and Metabolism in vitro of Zoxazolamine in Ageing Mice. Nature 233, 565–566 (1971). https://doi.org/10.1038/233565a0
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DOI: https://doi.org/10.1038/233565a0
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