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Quantitative Method for assessing One Symptom of the Withdrawal Syndrome in Mice after Chronic Morphine Administration

Nature volume 234, pages 223–224 (1971)Cite this article

Abstract

FEW quantitative methods exist for assessing the effects of withdrawing morphine from addicted laboratory animals. The aim of the experiments described here was to assess whether a method which depends on the number of characteristic vertical jumps made by mice after morphine withdrawal1 could be used as a measure of the withdrawal syndrome. This simple method has now been found to give reasonably repeatable and consistent results.

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Author notes

  1. MARTA WEINSTOCK

    Present address: Department of Pharmacology and Physiology Tel Aviv University Medical School, Beilinson Hospital, PO Box 85, Petak Tikva, Israel

Authors and Affiliations

  1. Department of Pharmacology, St Mary's Hospital Medical School, London, W2

    IAN MARSHALL & MARTA WEINSTOCK

Authors
  1. IAN MARSHALL
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  2. MARTA WEINSTOCK
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MARSHALL, I., WEINSTOCK, M. Quantitative Method for assessing One Symptom of the Withdrawal Syndrome in Mice after Chronic Morphine Administration. Nature 234, 223–224 (1971). https://doi.org/10.1038/234223a0

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