Abstract
THE action of growth hormone (GH) on skeletal tissue was proposed to be mediated through a secondary substance, described by the operational term “sulphation factor”1. The observations underlying this hypothesis have been amply confirmed and extended. A GH-dependent plasma factor stimulates in cartilage not only the incorporation of sulphate into chondroitin sulphate, but also the incorporation of thymidine into DNA2, proline into the hydroxyproline of collagen3 and uridine into RNA4. GH has substantially no in vitro effect on cartilage metabolism.
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References
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DAUGHADAY, W., HALL, K., RABEN, M. et al. Somatomedin: Proposed Designation for Sulphation Factor. Nature 235, 107 (1972). https://doi.org/10.1038/235107a0
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DOI: https://doi.org/10.1038/235107a0
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