Abstract
REPEATED inoculation of mouse interferon preparations inhibits the growth of several murine transplantable tumours and increases the survival of tumour inoculated mice1–6. The mechanism of this antitumour action of interferon in vivo is unknown. Since comparable interferon preparations inhibited the division of murine leukaemia L 1210 and Ehrlich ascites (EA) cells in suspension cultures7–9 it is possible that interferon also acts in vivo by inhibiting tumour cell multiplication. It is also possible, however, that interferon enhances in some manner the capacity of the host to reject the transplanted tumour.
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References
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GRESSER, I., MAURY, C. & BROUTY-BOYÉ, D. Mechanism of the Antitumour Effect of Interferon in Mice. Nature 239, 167–168 (1972). https://doi.org/10.1038/239167a0
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DOI: https://doi.org/10.1038/239167a0
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