Abstract
AFTER a single injection of morphine or related narcotic analgesics, incorporation of 14C-tyrosine into 14C-catecholamines is increased markedly in the brains of mice1,2 and rats3. However, repeated administration of these drugs results in the development of tolerance to their effects upon 14C-catecholamine synthesis1,2. We have determined that once complete tolerance has developed, the mouse brain cannot maintain normal rates of catecholamine synthesis without the continued administration of morphine.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Smith, C. B., Villarreal, J. E., Bednarczyk, J. H., and Sheldon, M. I., Science, 170, 1106 (1970).
Smith, C. B., Sheldon, M. I., Bednarczyk, J. H., and Villarreal, J. E., J. Pharmacol. Exp. Ther., 180, 547 (1972).
Clouet, D. H., and Ratner, M., Science, 168, 854 (1970).
Steinberg, M. I., and Smith, C. B., J. Pharmacol. Exp. Ther., 173, 176 (1970).
Weiner, N., and Rabadjija, M., J. Pharmacol. Exp. Ther., 160, 61 (1968).
Rethy, C. R., Smith, C. B., and Villarreal, J. E., J. Pharmacol. Exp. Ther., 176, 472 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROSENMAN, S., SMITH, C. 14C-Catecholamine Synthesis in Mouse Brain during Morphine Withdrawal. Nature 240, 153–155 (1972). https://doi.org/10.1038/240153a0
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1038/240153a0
This article is cited by
-
Simultaneous measurement of biogenic amines and their metabolites in rat brain regions after acute administration of and abrupt withdrawal from butorphanol or morphine
Neurochemical Research (1995)
-
The fall of homovanillic acid and 5-hydroxyindoleacetic acid concentrations in brains of mice withdrawn from repeated morphine treatment and their restoration by acute morphine administration
Journal of Neural Transmission (1987)
-
Retardation of cerebral dopamine turnover after morphine withdrawal and its enhanced acceleration by acute morphine administration in rats
Naunyn-Schmiedeberg's Archives of Pharmacology (1984)
