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Nucleolar localization of the carboxy-truncated form of the signal transducer and activator of transcription 5 (STAT5β) detected in CML and AML5

Leukemia volume 18, pages 1144–1145 (2004)Cite this article

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TO THE EDITOR

Leukemias are characterized by deregulation of hematopoietic cell differentiation and/or resistance to apoptosis. Among proteins involved in regulation of these pathways and suspected to play an important role in leukemogenesis are the Jak and STAT proteins. STAT (signal transducer and activator of transcription) 5a and STAT5b proteins are latent cytoplasmic transcription factors that translocate to the nucleus upon activation by cytoplasmic Jak tyrosine kinases. They participate in elemental cell biologic processes, including cellular growth, cell cycle progression and apoptosis. Based on several reports of STAT5 constitutive activation in leukemic cells, it has been hypothesized that STAT5 proteins may play an important role in leukemia.

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Acknowledgements

We acknowledge F Gouilleux for critical reviews of the manuscript, NOVARTIS for the gift of STI571, Dr Danielle Bensoussan and Emile Brunner and Elias Bechara for technical assistance. This study was supported by la Ligue Nationale contre le Cancer and la Fondation de France contre la Leucémie. NT was supported by a fellowship from le Comité Lorrain de La Ligue Départementale Contre le Cancer, and from La Fondation de France Bourse Michel et Lidy Witner.

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Authors and Affiliations

  1. Laboratoire de Génétique Médicale, CHU Nancy-Brabois, 3441, EA, France

    N Touche, C Philippe & P Jonveaux

  2. Laboratoire de Biologie Cellulaire du Développement, UPRES 2402 ‘Proliférateurs de péroxysomes’, Université Henry Poincaré, Nancy, France

    H Schohn

  3. Laboratoire d'Anatomo-pathologie, Secteur Cytologie, CHU Nancy-Brabois, France

    C Bonnet & F Plénat

  4. Service d'Hématologie Biologique, Secteur Cytologie, CHU Nancy-Brabois, France

    J Buisine

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  1. N Touche
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  2. H Schohn
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  3. C Bonnet
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  5. F Plénat
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  6. C Philippe
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Correspondence to P Jonveaux.

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Touche, N., Schohn, H., Bonnet, C. et al. Nucleolar localization of the carboxy-truncated form of the signal transducer and activator of transcription 5 (STAT5β) detected in CML and AML5. Leukemia 18, 1144–1145 (2004). https://doi.org/10.1038/sj.leu.2403371

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