Table 1 Characteristics of patients
From: Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis
WHO criteria | PVSG criteria | WHO and PVSG criteria | ||||
|---|---|---|---|---|---|---|
PV (n=61) | Idiopathic erythrocytosis (n=11) | PV (n=45) | Idiopathic erythrocytosis (n=21) | Secondary erythrocytosis (n=5) | Ht>50%, but no AE (n=3) | |
Sex ratio (male/female) | 38/23 | 11/0 | 28/17 | 18/3 | 4/1 | 3/0 |
Median age (range) | 61(23–92) | 57(24–81) | 58(23–92) | 60(53–81) | 65 (55–77) | 48.6 |
Mean Ht (%)±s.d. | 59±4.6 | 54.6±1.44 | 59.2±4.5 | 57.8±4.2 | 55.8±3.1 | 53.3±0.8 |
Mean Hb (g/dl)±s.d. | 19.2±1.39 | 18.3±0.34 | 19.3±1.41 | 19±1.0 | 18.9±0.8 | 18.6±0.5 |
Mean WBC (× 109)±s.d. | 12.2±4.4 | 7.0±2.5 | 13.5±4.9 | 8.2±2.5 | 8.8±1.9 | 6.6±0.4 |
Mean platelet count (× 109)±s.d. | 463±148 | 212±38 | 503±149 | 245±60.4 | 212±29 | 175±19 |
Splenomegaly | 16/55 | 0/11 | 14/39 | 0/21 | 0/5 | 0/3 |
Presence of EEC | 59/60 | 0/11 | 43/44 | 11/21 | 0/5 | 0/3 |
Low Epo level | 39/47 | 2/8 | 27/33 | 10/17 | 0/3 | 1/1 |
Normal Epo level | 8/47 | 6/8 | 6/33 | 7/17 | 3/3 | 0/1 |
Cytogenetic abnormalities | 7/32 | 0/3 | 6/23 | 0/7 | nd | 0/1 |
JAK2 V617F positive | 57/61 | 0/11 | 43/45 | 8/21 | 0/5 | 0/3 |
