Abstract
THE effects of D-amphetamine on the colonic temperature of rats depend on the ambient temperature1. Rats kept in cold environments (4°–15° C, relative humidity 45%) exhibit profound hypothermia for at least 90 min after receiving D-amphetamine (7.5–15 mg/kg, given intraperitoneally). The same doses cause marked hyperthermia among rats kept at room temperature (20° C) or in a warm environment (37° C). The evidence we report here suggests that the D-amphetamine-induced hypothermia is mediated by the release of dopamine from brain neurones.
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YEHUDA, S., WURTMAN, R. Release of Brain Dopamine as the Probable Mechanism for the Hypothermic Effect of D-Amphetamine. Nature 240, 477–478 (1972). https://doi.org/10.1038/240477a0
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DOI: https://doi.org/10.1038/240477a0
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