Abstract
MORPHINE has a variety of pharmacological effects including inhibition of motility of some types of smooth muscle1,2. The narcotic antagonists nalorphine and naloxone appear to reverse a majority of the pharmacological effects of morphine by competitive inhibition for the tissue receptor site1,2. Our study was designed to determine if antibodies reactive with morphine could also inhibit or successfully reverse one of the biologic actions of the drug. We examined the capacity of rabbit antibodies produced by immunization with 6-succinyl-morphine conjugated to bovine serum albumin (M-6-HS-BSA)3,4 to antagonize the depressant action of morphine on electrically-induced contractions of isolated guinea pig ileum.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schuster, C. R., and Villarreal, J. E., in Psychopharmacology, A Review of Progress 1957–1967 (edit. by Efron, D. H.) (Public Health Service Publication No. 1836, 1968).
Jaffe, J. H., in The Pharmacological Basis of Therapeutics (edit. by Goodman, L.S., and Gilman, A.), 237 (Macmillan, New York, 1970).
Wainer, B. H., Fitch, F. W., Rothberg, R. M., and Fried, J., Science, 176, 1143 (1972).
Wainer, B. H., Fitch, F. W., Rothberg, R. M., and Fried, J., Science, 178, 647 (1972).
Wainer, B. H., Fitch, F. W., Fried, J., and Rothberg, R. M., J. Immunol. (in the press).
Farr, R. S., J. Infect. Dis., 103, 239 (1958).
Minden, P., and Farr, R. S., in Handbook of Experimental Immunology (edit. by Weir, D. M.), 463 (Davis, Philadelphia, 1967).
Gyang, E. A., and Kosterlitz, H. W., Br. J. Pharmac. Chemother., 27, 514 (1966).
Kosterlitz, H. W., and Watt, A. J., Br. J. Pharmac. Chemother., 33, 266 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WAINER, B., FITCH, F., ROTHBERG, R. et al. In vitro Morphine Antagonism by Antibodies. Nature 241, 537–538 (1973). https://doi.org/10.1038/241537a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/241537a0
This article is cited by
-
The M3-TT Vaccine Decreases the Antinociceptive Effects of Morphine and Heroin in Mice
International Journal of Mental Health and Addiction (2023)
-
Immunological correlation between morphine tolerance and the effect of naloxone in rats of different age
Bulletin of Experimental Biology and Medicine (1996)
-
Morphine and related compounds — Stimulators of synthesis of specific antiboides (literature review)
Pharmaceutical Chemistry Journal (1978)
-
Prevention of the effects of fentanyl by immunological means
Nature (1975)
-
Effect of morphine in vitro on oxidative phosphorylation in rat liver mitochondria
Bulletin of Experimental Biology and Medicine (1975)
