Abstract
MAMMALIAN egg cells, like other cells, can be fused in culture in the presence of a virus1,2. But because many viruses do not infect eggs which possess a zona pellucida3, fusion of egg cells has been performed after its removal. This manipulation reduces the rate of successful development in early cleavage eggs4, which if transferred to recipient oviducts adhere to the epithelium and degenerate5. Now we report multinucleation and nuclear fusion within the zona pellucida of mouse eggs injected with a suspension of Sendai virus and somatic cells into the perivitelline cavity.
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LIN, T., FLORENCE, J. & OH, J. Cell Fusion induced by a Virus within the Zona Pellucida of Mouse Eggs. Nature 242, 47–49 (1973). https://doi.org/10.1038/242047a0
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DOI: https://doi.org/10.1038/242047a0
