Abstract
ALLOANTIGENS expressed on one cell type but not on another provide the basis for homograft reactions directed against particular tissues. The Sk alloantigens of mice are expressed on epidermal cells but not on haemopoietic cells1. Thus C57B1/6 (B6) mice that have been lethally irradiated and restored with (B6 × A)F1 spleen and bone marrow cells [abbreviated to (B6 × A)-to-B6 chimaeras] invariably reject (B6 × A) and A strain skin although they are permanent haemopoietic chimaeras. Rejection is accompanied by the production of antibody which is cytotoxic for A strain epidermal cells but not for A strain haemopoietic cells of any type2. The antigen thus recognized, Sk.1, is absent from all tissues of B6 mice; B6 epidermal cells carry the alternative alloantigen Sk.2.
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References
Boyse, E. A., Lance, E. M., Carswell, E. A., Cooper, S., and Old, L. J., Nature, 227, 901 (1970).
Scheid, M., Boyse, E. A., Carswell, E. A., and Old, L. J., J. Exp. Med., 135, 938 (1972).
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BOYSE, E., CARSWELL, E., SCHEID, M. et al. Tolerance of Sk-incompatibte Skin Grafts. Nature 244, 441–442 (1973). https://doi.org/10.1038/244441a0
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DOI: https://doi.org/10.1038/244441a0
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