Abstract
ABUNDANT clinical and experimental evidence indicates that the hippocampus is involved in temporal lobe epilepsy1,2. Some of the symptoms of excitation associated with the disease may be related to the marked tendency of the hippocampus to produce seizures in response to mechanical, electrical and chemical stimuli3. Focal discharges in the temporal lobe could spread through direct afferents to the nearby entorhinal cortex4. Excitatory projections from entorhinal neurones form the final link in the chain between the sensory neocortex and the hippocampus by making synaptic contact with granule cells of the dentate gyrus. Axons arising from the granule cells synapse, in turn, on the apical dendrites of CA3–4 hippocampal pyramidal cells. These axons comprise the mossy fibre pathway5.
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References
Gastaut, H., and Broughton, R., Epileptic Seizures (Thomas, Springfield, 1972).
Jasper, H. H., Ward, A. A., and Pope, A., Basic Mechanisms of Epilepsies (Little, Brown, Boston, 1967).
Green, J. D., Physiol. Rev., 44, 561 (1964).
Van Hoesen, G. W., Pandya, D. N., and Butters, N., Science, N.Y., 175, 1471 (1972).
Andersen, P., Blackstad, T. W., and Lömo, T., Expl. Brain Res., 1, 236 (1966).
Curtis, D. R., and Watkins, J. C., Pharmacol. Rev., 17, 347 (1965).
Krnjevic, K., Nature, 228, 119 (1970).
Crawford, I. L., and Connor, J. D., Fed. Proc., 32, 696 (1973).
Schmidt, E., Methods of Enzymatic Analysis (edit. by Bergmeyer, H.), 752 (Academic, New York, 1965).
Berl, S., Takagaki, G., Clarke, D. D., and Waelsch, H., J. biol. Chem., 237, 2562 (1962).
Adelstein, S. J., and Valee, B. L., J. biol. Chem., 223, 3 (1958).
Maske, H., Naturwissenschaften, 42, 424 (1955).
Haug, F.-M. S̄., Histochemie, 8, 355 (1967).
von Euler, C., in Physiologie de l'Hippocampe (edit. by Passouant, A.), 135 (Editions du CNRS, Paris, 1962).
Crawford, I. L., and Connor, J. D., J. Neurochem., 19, 1451 (1972).
Colburn, R. W., and Maas, J. W., Nature, 208, 37 (1965).
Gramacioli, C. M., Acta Cryst., 21, 600 (1966).
Biscoe, T. J., and Straughan, D. W., J. Physiol., 183, 341 (1966).
Koyama, I., Can. J. physiol Pharmacol., 50, 740 (1972).
Tower, D. B., Neurochemistry of Epilepsy (Thomas, Springfield, 1960).
Van Gelder, N. M., Sherwin, A. L., and Rasmussen, T., Brain Res., 40, 385 (1972).
Gottesfield, Z., and Elazar, Z., Nature, 240, 478 (1972).
Graham, jun., L. T., and Aprison, M. H., Analyt. Biochem., 15, 487 (1966).
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CRAWFORD, I., CONNOR, J. Localization and Release of Glutamic Acid in Relation to the Hippocampal Mossy Fibre Pathway. Nature 244, 442–443 (1973). https://doi.org/10.1038/244442a0
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DOI: https://doi.org/10.1038/244442a0
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