Abstract
EXTENSIVE studies on the seminal plasma of man and other species have attempted to define the role of various components on the metabolism of spermatozoa, on the female reproductive tract and on the motility of spermatozoa and their capacity to fertilize the ovum1–7. These studies have provided evidence of a role for fructose, cyclic AMP, prostaglandins and other constituents1,8. We report here a newly discovered small molecular weight substance in human seminal plasma with a beneficial effect on the fertilization by epididymal sperm of ova of two mammalian species.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mann, T., The Biochemistry of Semen and of the Male Reproductive Tract (Wiley, New York, 1964).
Mann, T., in Fertilization, Sperm Metabolism (edit. by Metz, C. B., and Monroy, A.), 1, 99 (Academic Press, New York, 1967).
Nelson, L., in Fertilization, Sperm Motility (edit. by Metz, C. B., and Monroy, A.), 1, 27 (Academic Press, New York, 1967).
Pautard, F. G. E., in Spermatozoan Motility, Biomolecular Aspects of Spermatozoan Motility (edit. by Bishop, D. W.), 189 (Amer. Assoc. Adv. Sci., Washington, DC, 1962).
Rozin, S., Fertil. Steril., 11, 278 (1960).
Bishop, D. W., Physiol. Rev., 42, 1 (1962).
Juan, J. H., Neives, P., and Adolfo, R., Fertil. Steril., 23, 886 (1972).
Kirton, K., Duncan, G., Oesterling, T., and Forbes, A., Annals of the New York Academy of Sciences, Prostaglandins and Reproduction in Rhesus Monkey (edit. by Ramwell, P., and Shaw, J. E.), 180, 445 (Academy of Sciences, New York, 1971).
Pauly, M., Hoppe-Seyl. Z. physiol. Chem., 42, 508 (1904).
Gaur, R. D., Goswami, A. K., and Talwar, G. P., Indian J. Med. Res., 60, 932 (1972).
Miyamoto, H., and Chang, M. C., J. Reprod. Fert., 30, 135 (1972).
Whitten, W. K., in Schering Symposium on Intrinsic and Extrinsic Factors in Early Mammalian Development (edit. by Raspe, G.) (Advances in Biosciences, 6) (Pergamon/Vieweg, 1970).
Whitten, W. K., and Biggers, J. D., J. Reprod. Fert., 17, 399 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GAUR, R., TALWAR, G. Isolation of a Factor from Human Seminal Plasma that Promotes Fertilization. Nature 244, 450–452 (1973). https://doi.org/10.1038/244450a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/244450a0