Abstract
The interaction of antigen with antigen-sensitive cells can lead to antibody synthesis (induction) or can render these cells non-inducible (paralysis). Cyclic AMP may be the intracellular mediator of a paralytic signal whereas both cyclic AMP and cyclic GMP may be required as mediators of an inductive signal.
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References
Bretscher, P., and Cohn, M., Science, N.Y., 169, 1042 (1970).
Watson, J., Trenkner, E., and Cohn, M., J. exp. Med., 138, 699 (1973).
Watson, J., Epstein, R., Nakoinz, I., and Ralph, P., J. Immunol., 110, 43 (1973).
Andersson, J., Möller, G., and Sjöberg, O., Cell. Immunol., 4, 381 (1972).
Chiller, J., and Weigle, W. O., J. exp. Med., 135, 714 (1973).
Osborne, D. P., and Katz, D. H., J. exp. Med., 137, 991 (1973).
Butcher, R. W., Robison, G. A., and Sutherland, E. W., in Control Processes in Multicellular Organisms (edit. by Wolsten-holme, G. E. W., and Knight, J.), 64 (Churchill, London, 1970).
Burger, M. M., Bombik, B. J., Breckenridge, B. McL., and Sheppard, J. R., Nature new Biol., 239, 161 (1972).
Pastan, I., and Perlman, R. L., Nature new Biol., 229, 5 (1971).
Smets, L. A., Nature new Biol., 239, 123 (1972).
Sheppard, J. R., Nature new Biol., 236, 14 (1972).
Kirkland, W. L., and Burton, P. R., Nature new Biol., 240, 205 (1972).
Tomkins, G. M., in Adv. Cell Biol. (edit. by Prescott, D. M., Goldstein, L., and McConkey, E.), 2, 299 (Appleton-Century-Crofts, New York, 1972.)
Wicks, W. D., Science, N.Y., 160, 997 (1968).
Kreider, J. W., Rosenthal, M., and Lengle, N., J. natn. Cancer Inst., 50, 555 (1973).
Johnson, G. S., and Pastan, I., Nature new Biol., 237, 267 (1972).
Daniels, V., Litwack, G., and Tomkins, G. M., Proc. natn. Acad. Sci. U.S.A., 70, 76 (1973).
Ishizuka, M., Gafni, M., and Braun, W., Proc. Soc. exp. biol. Med., 134, 963 (1970).
Ishizuka, M., Braun, W., and Matsumoto, T., J. Immunol., 107, 1027 (1971).
Braun, W., and Ishizuka, M., J. Immunol., 107, 1036 (1971).
Bösing-Schneider, R., and Kolb, H., Nature, 244, 224 (1973).
Kaukel, E., and Hilz, H., Biochem. biophys. Res. Comm., 46, 1011 (1972).
Triner, L., Vulliemoz, Y., Schwartz, I., and Nahas, G. G., Biochem. biophys. Res. Comm., 40, 64 (1970).
Weigle, W. O., Chiller, J. M., and Habicht, G. S., in Prog. Immunol. (edit. by Amos, B.), 1, 311 (Academic Press, New York, 1970).
Hadden, J. W., Hadden, E. M., Haddox, M. K., and Goldberg, N., Proc. natn. Acad. Sci. U.S.A., 69, 3024 (1972).
Franks, D. J., and MacManus, J. P., Biochem. biophys. Res. Comm., 42, 844 (1971).
Beavo, J. A., Hardman, J. G., and Sutherland, E. W., J. biol. Chem., 245, 5649 (1970).
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WATSON, J., EPSTEIN, R. & COHN, M. Cyclic Nucleotides as Intracellular Mediators of the Expression of Antigen-sensitive Cells. Nature 246, 405–409 (1973). https://doi.org/10.1038/246405a0
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DOI: https://doi.org/10.1038/246405a0
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