Abstract
ONE of the characteristics of cystic fibrosis (CF), an autosomal recessive disease, is a defect in the net sodium transport in the eccrine glands resulting in an increased concentration of sodium in the sweat1. This defect has yet to be characterised as an extrinsic and/or intrinsic phenomenon. Mangos and McSherry2 demonstrated an unidentified factor in the sweat from CF patients which inhibited sodium reabsorption in the rat parotid duct after retrograde perfusion. The relationship of the sweat factor to factors observed in saliva3 and sera4,5 of CF patients has yet to be elucidated.
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QUISSELL, D., PITOT, H. Number of Ouabain-binding Sites in Fibroblasts from Normal Subjects and Patients with Cystic Fibrosis. Nature 247, 115–116 (1974). https://doi.org/10.1038/247115a0
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DOI: https://doi.org/10.1038/247115a0
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