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Evidence for Individual Human Peripheral Blood Lymphocytes bearing both B and T Cell Markers

Nature volume 247, pages 213–215 (1974)Cite this article

Abstract

LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluorescence-detectable surface immunoglobulin1–3 and by their ability to bind antigen-antibody complexes or heat-aggregated immunoglobulin through the Fc portion of the immunoglobulin molecule4–7. Human T cells can be identified by their ability to form non-immune rosettes (E rosettes) with sheep red blood cells (SRBC)8–12. We report here that when these B and T cell markers were evaluated simultaneously oh individual cells, a small subpopulation reproducibly bore both markers. Further experiments seemed to rule out artefact as an explanation.

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Author notes

  1. N. F. ADKINSON jun.

    Present address: Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Maryland, 21239

Authors and Affiliations

  1. Immunology Branch, National Cancer Institute, Bethesda, Maryland, 20014

    H. B. DICKLER, N. F. ADKINSON jun. & W. D. TERRY

Authors
  1. H. B. DICKLER
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  2. N. F. ADKINSON jun.
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  3. W. D. TERRY
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DICKLER, H., ADKINSON, N. & TERRY, W. Evidence for Individual Human Peripheral Blood Lymphocytes bearing both B and T Cell Markers. Nature 247, 213–215 (1974). https://doi.org/10.1038/247213a0

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