Abstract
RECENT experiments by Carp et al.1,2 and Licursi et al.3 have excited hopes among investigators of multiple sclerosis (MS) and slow virus infections of the central nervous system that an experimental marker for these diseases has finally been found. Tissues from humans with MS or from scrapie mice were inoculated into normal mice, which showed a polymorphonuclear leukocyte (PMN) depression beginning within 1 to 3 d of the inoculation and persisting many months thereafter.
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References
Carp, R. I., Licursi, P. C., Merz, P. A., and Merz, G. S., J. exp. Med., 136, 618 (1972).
Carp, R. I., Merz, P. A., Licursi, P. C., and Merz, G. S., J. infect. Dis., 128, 256 (1973).
Licursi, P. C., Merz, P. A., Merz, G. S., and Carp, R. I., Infect. Immun., 6, 370 (1972).
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BROWN, P., GAJDUSEK, D. No Mouse PMN Leukocyte Depression after Inoculation with Brain Tissue from Multiple Sclerosis or Spongiform Encephalopathies. Nature 247, 217–218 (1974). https://doi.org/10.1038/247217a0
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DOI: https://doi.org/10.1038/247217a0
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