Abstract
IMMUNOGLOBULIN (Ig) molecules on the surfaces of metabolically active mouse lymphocytes are redistributed into “caps” when crosslinked with fluorescent, ferritin-conjugated or 125I-labelled anti-Ig antibody at room temperature or 37° C1–3. Caps of labelled Ig–anti-Ig complexes form over the Golgi region of the cell, and are rapidly ingested by endocytosis2,3 Capping of receptors for the plant lectin concanavalin A (con A) on mouse lymphoid cells is also accompanied by considerable endocytosis of label3,4. On the other hand, little or no internalisation of label occurs after capping of H-21,3 and Thy-1 (θ)1 alloantigens on mouse lymphocytes and thymocytes, and anti-lymphocyte globulin receptors on rat spleen cells3.
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STACKPOLE, C., JACOBSON, J. & LARDIS, M. Two Distinct Types of Capping of Surface Receptors on Mouse Lymphoid Cells. Nature 248, 232–234 (1974). https://doi.org/10.1038/248232a0
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DOI: https://doi.org/10.1038/248232a0
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