Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Stimulation of calcitonin synthesis and release in vitro by calcium and dibutyryl cyclic AMP

Nature volume 248, pages 343–344 (1974)Cite this article

Abstract

IT has been proposed that the physiological action of calcitonin is to prevent or diminish postprandial hypercalcaemia1. This is accomplished by inhibition of bone resorption2, of the tubular reabsorption of calcium3, and of the intestinal absorption of calcium4. Secretion or release of the hormone by parafollicular cells of the thyroid gland is mediated by calcium5–7 and by gastrointestinal hormones including gastrin and pancreozymin8,9. Secretion is apparently influenced by the adenylate cyclase system 7,10 and hormonal regulation presumably is mediated by cyclic adenosine 3′, 5′-monophosphate (cyclic AMP).

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gray, T. K., and Munson, P. L., Science, N. Y., 166, 512 (1969).

    Article  CAS  ADS  Google Scholar 

  2. Friedman, J., and Raisz, L. G., Science, N.Y., 150, 1465 (1965).

    Article  CAS  ADS  Google Scholar 

  3. Ardaillou, R., Vuagnat, P., Milhaud, G., and Richet, G., Nephron, 4, 298 (1967).

    Article  CAS  Google Scholar 

  4. Olson, E. B., DeLuca, H. F., and Potts, J. T., jun., Endocrinology, 90, 151 (1972).

    Article  CAS  Google Scholar 

  5. Care, A. D., Cooper, C. W., Duncan, T., and Orimo, H., Endocrinology, 83, 161 (1968).

    Article  CAS  Google Scholar 

  6. Lee, M. R., Deftos, L. J., and Potts, J. T., jun., Endocrinology, 84, 36 (1969).

    Article  CAS  Google Scholar 

  7. Bell, N. H., J. clin. Invest., 49, 1368 (1970).

    Article  CAS  Google Scholar 

  8. Care, A. D., Bates, R. F. L., Swaminathan, R., and Ganguli, P. C., J. Endocr., 51, 735 (1971).

    Article  CAS  Google Scholar 

  9. Care, A. D., Bruce, J. B., Boelkins, J., Kenny, A. D., Conoway, H., and Anast, C., Endocrinology, 89, 262 (1971).

    Article  CAS  Google Scholar 

  10. Care, A. D., Bates, R. F. L., and Gitelman, H. J., J. Endocr., 48, 1 (1970).

    Article  CAS  Google Scholar 

  11. Bell, N. H., Nature new Biol., 245, 85 (1973).

    Article  CAS  Google Scholar 

  12. Gudmundsson, T. V., Byfield, P. G. H., Galente, L., and Maclntyre, I., in Calcitonin: Proceedings of the Symposium on Thyrocalcitonin and the C Cells (edit. by Taylor, S. F.), 51 (William Heinemann Medical Books Ltd., London, 1968).

    Book  Google Scholar 

  13. Gittes, R. F., Toverud, S. U., and Cooper, C. W., Endocrinology, 82, 83 (1968).

    Article  CAS  Google Scholar 

  14. Tanese, T., Lazarus, N. R., Devrim, S., and Recant, L., J. clin. Invest., 49, 1394 (1970).

    Article  CAS  Google Scholar 

  15. Abe, M., and Sherwood, L. M., Biochem. biophys. Res. Commun., 48, 396 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine, Pharmacology and Biochemistry, Indiana University Medical School and V A Hospital, Indianapolis, Indiana, 46202

    NORMAN H. BELL & SHERRY QUEENER

Authors
  1. NORMAN H. BELL
    View author publications

    Search author on:PubMed Google Scholar

  2. SHERRY QUEENER
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BELL, N., QUEENER, S. Stimulation of calcitonin synthesis and release in vitro by calcium and dibutyryl cyclic AMP. Nature 248, 343–344 (1974). https://doi.org/10.1038/248343a0

Download citation

  • Received:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/248343a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing