Abstract
SEVERAL attempts have been made to show the specific localisation in vivo of anti-tumour antibodies. Most of these studies, however, either in experimental animals1,2 or in humans3 were performed with antibodies obtained by adsorption and elution from poorly characterised crude tumour fractions.
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References
Korngold, L., and Pressman, D., Cancer Res., 14, 96 (1964).
Day, E. D., Planinsek, J. A., and Pressman, D., J. natn. Cancer Inst., 25, 787 (1960).
Day, E. D., Lassiter, S., and Mahaley, M. S., jun., J. nucl. Med., 6, 38 (1965).
Sordat, B., Fritsché, R., Mach, J.-P., Carrel, S., Ozzello, L., Cerottini, J.-C., Proc. first int. Workshop on Nude Mice, Scanticon Okt. 1973 (in the press).
Gold, P., and Freedman, S. O., J. exp. Med., 122, 467 (1965).
Pusztaszeri, G., and Mach, J.-P., Immunochemistry. 10, 197 (1973).
Krupey, J., Gold, P., and Freedman, S. O., J. exp. Med., 128, 387 (1968).
Thomson, D. M. P., Krupey, J., Freedman, S. O., and Gold, P., Proc. natn. Acad. Sci., U.S.A., 64, 161 (1969).
Mach, J.-P., MacDonald, D., and Bertholet, M.-M., Proc. seventh Miles int. Symp. 1973: The role of immunological factors in viral, and oncogenic processes (Johns Hopkins Press, Baltimore, in the press).
Egan, M. I., Lautenschleger, J. T., Coligin, J. E., and Todd, C. W., Immunochemistry, 9, 289 (1972).
Laurence, D. J. R., Stevens, U., Bettelheim, R., Carcy, D., Leese, C., Tuberville, C., Alexander, P., Johns, E. W., and Neville, A. M., Bri. med. J., 3, 605 (1972).
Avrameas, S., and Ternynck, T., Immunochemistry, 6, 53 (1969).
Mach, J.-P., and Pusztaszeri, G., Immunochemistry, 9, 1031 (1972).
von Kleist, S., Chavanel, G., and Burtin, P., Proc. natn. Acad. Sci., U.S.A., 69, 2492 (1972).
Darcy, D. A., Tuberville, C., and James, R., Br. J. Cancer, 28, 147 (1973).
Dandliker, W. B., de Saussure, V. A., and Levandoski, N., Immunochemistry, 5, 357 (1968).
Marchalonis, J. J., Biochem. J., 113, 299 (1969).
Cerottini, J.-C., and Isliker, H., Eur. J. Cancer, 3, 111 (1967).
Martin, F., and Martin, M. S., Int. J. Cancer, 6, 352 (1970).
Burtin, P., Martin, E., Sabine, M. C., and von Kleist, S., J. natn. Cancer Inst., 48, 25 (1972).
Lo Gerfo, P., Herter, F. P., Braun, J., and Hansen, H. J., Ann. Surg., 175, 495 (1972).
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MACH, JP., CARREL, S., MERENDA, C. et al. In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature 248, 704–706 (1974). https://doi.org/10.1038/248704a0
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DOI: https://doi.org/10.1038/248704a0
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