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Levamisole inactive in treatment of four animal tumours

Nature volume 249, pages 567–569 (1974)Cite this article

Abstract

LEVAMISOLE (2,3,5,6-tetrahydro-6-phenylimidazo (2, 1-b) thiazole) a compound known to be active against a wide range of nematodes1,2, has been reported to enhance the humoral and cellular immune responses of animals and to reduce the incidence of both primary tumours and lung metastases in the Lewis lung (3a) tumour system in C57BL mice3. We report here studies on the effect of levamisole on the growth of four transplantable tumours, all known to be immunogenic. They were: a transplantable adenovirus 12-induced tumour of CBA mice4; a chick embryo lethal orphan (CELO) virus-induced tumour of hamsters5; a Moloney leukaemia virus-induced lymphoma of BALB/c mice6; and a chemically-induced metastasising anaplastic neoplasm of inbred rats7. We also studied the effect of levamisole on the humoral antibody response to influenza virus vaccine in hamsters.

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Authors and Affiliations

  1. Division of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield, UK

    C. W. POTTER, I. CARR, R. JENNINGS, R. C. REES, F. MCGINTY & V. M. RICHARDSON

Authors
  1. C. W. POTTER
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  2. I. CARR
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  3. R. JENNINGS
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  4. R. C. REES
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  5. F. MCGINTY
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  6. V. M. RICHARDSON
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POTTER, C., CARR, I., JENNINGS, R. et al. Levamisole inactive in treatment of four animal tumours. Nature 249, 567–569 (1974). https://doi.org/10.1038/249567a0

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