Abstract
THE unstable haemoglobins form a well-characterised group of human mutants which have been observed in many parts of the world1. We have recently cooperated in the study of two such haemoglobins seen in Moscow. Haematological and clinical aspects have been published in Russia2,3. One of the haemoglobins, discovered in a mildly anaemic patient who had pancreatitis (and in his son), was found to be Hb Tacoma (β30 (B12) Arg → Ser), previously described in three members of a United States Caucasian family4. As this haemoglobin has already been fully characterised5 it will not be discussed further here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Lehmann, H., and Carrell, R. W., Br. Med. Bull., 25, 14–23 (1969).
Idelson, L. I., Didkovsky, N. A., Volkova, M. A., Fleischman, E. V., Troitskaya, O. V., Margulis, M. I., and Filippova, A. V., Problemy Gemat. Pereliv. Krovi, 15, 29–31 (1971).
Didkovsky, N. A., Filippova, A. V., and Idelson, L. I., Problemy. Gemat. Pereliv. Krovi, 17, 38–45 (1972).
Baur, E. W., and Motulsky, A. G., Humangenetik, 1, 621–634 (1965).
Brimhall, B., Jones, R. T., Baur, E. W., and Motulsky, A. G., Biochemistry, 8, 2125–2129 (1969).
Rigas, D. A., and Koler, R. D., Blood, 18, 1–17 (1961).
Dacie, J. V., Grimes, A. J., Meisler, A., Steingold, L., Hemsted, E. H., Beaven, G. H., and White, J. C., Br. J. Haemat., 10, 338–402 (1964).
Carrell, R. W., and Kay, R., Br. J. Haemat., 23, 615–619 (1972).
Poulik, M. D., Nature, 180, 1477–1479 (1957).
Huisman, T. H. J., and Dozy, A. M., J. Chromat. 19, 160–169 (1965).
Cradock-Watson, J. E., Fenton, J. C. B., and Lehmann, H., J. clin. Path., 12, 372–373 (1959).
Sick, K., Beale, D., Irvine, D., Lehmann, H., Goodall, P. T., and MacDougall, S., Biochim. biophys. Acta, 140, 231–242 (1966).
Gray, W. R., Meth. Enzymol., 11, 469–475 (1967).
Dayhoff, M. O., Atlas of protein sequence and structure, 5, (The National Biomedical Research Foundation, Silversprings, Maryland, 1972).
Romero-Herrera, A. E., Lehmann, H., Joysey, K. A., and Friday, A. E., Nature, 246, 389–395 (1973).
Ranney, H. M., Jacobs, A. S., Uden, L., and Zalusky, R., Biochem. biophys. Res. Commun., 33, 1004–1011 (1968).
Huisman, T. H. J., Brown, A. K., Efremov, G. D., Wilson, J. B., Reynolds, C. A., Uy, R., and Smith, L. L., J. clin. Invest., 50, 650–659 (1971).
Kilmartin, J. V., and Rossi-Bernardi, L., Biochem. J., 124, 31–45 (1971).
Imai, K., Morimoto, H., Kotani, M., Watari, H., Hirati, W., and Kuroda, M., Biochim. biophys. Acta., 200, 189–196 (1970).
Jones, R. T., Koler, R. D., Duerst, M., and Stocklen, Z., Hemoglobin and Red Cell Structure and Function (edit. by Brewer, G.), 79 (Plenum, New York, 1972).
Hyde, R. D., Hall, M. D., Wiltshire, B. G., and Lehmann, H., Lancet, ii, 1170–1172 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
IDELSON, L., DIDKOWSKY, N., CASEY, R. et al. New unstable haemoglobin (Hb Moscva, β24 (B4) Gly→Asp) found in the USSR. Nature 249, 768–770 (1974). https://doi.org/10.1038/249768a0
Received:
Issue date:
DOI: https://doi.org/10.1038/249768a0