Abstract
DOSE-RESPONSE studies of oncogenic viruses in animals are usually restricted to single inoculations. The study of the effect of dose fractionation has been a rather neglected subject in this field. An important question is whether the combined effect of the small doses is less than the effect of a single exposure to the same total dose. In this study on dose fractionation of a murine leukaemia virus we observed the opposite effect.
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BENTVELZEN, P., BRINKHOF, J. Leukaemogenic effect of repeated inoculations with small doses of Tennant virus in BALB/c mice. Nature 251, 155–156 (1974). https://doi.org/10.1038/251155a0
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DOI: https://doi.org/10.1038/251155a0
