Abstract
CERTAIN plasmids, including the colicin factor ColIb and the drug resistance transfer factor R-Utrecht, reduce the susceptibility of wild-type cells of Salmonella typhimurium to the lethal effects of ultraviolet irradiation while at the same time increasing their susceptibility to the mutagenic effects1,2. These alterations in ultraviolet response may result from plasmid-borne genes whose products participate in repair of single-strand gaps in DNA (ref. 2). Here I present evidence which indicates that at least part of the ultraviolet protection conferred on wild-type cells by R-Utrecht can be attributed to a plasmid-coded DNA polymerase which participates in repair of single strand gaps.
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MACPHEE, D. DNA polymerase activity determined by the ultraviolet-protecting plasmid, R-Utrecht. Nature 251, 432–434 (1974). https://doi.org/10.1038/251432a0
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DOI: https://doi.org/10.1038/251432a0
