Abstract
THERE is now abundant evidence that tumour cells express new surface antigens (tumour-associated antigens, TAA)1. In many tumour models, cell-mediated immunity directed against TAA has been demonstrated in vitro2. Serum from tumour-bearing individuals has been shown to inhibit specifically cell-mediated immune responses (CMI) to the tumour target cells in vitro3, and this phenomenon may explain the paradoxical coexistence of a growing tumour and an immune response directed against the tumour. Both immune complexes of TAA with antibody4,5, and soluble TAA alone6, have been implicated as inhibitors in these sera.
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SHELLAM, G., KNIGHT, R. Antigenic inhibition of cell-mediated cytotoxicity against tumour cells. Nature 252, 330–332 (1974). https://doi.org/10.1038/252330a0
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DOI: https://doi.org/10.1038/252330a0
