Abstract
NORMAL mice have in their lymphoid tissues a fairly large number of cells making antibody to antigens present within isologous erythrocytes1. These plaque-forming cells (PFC) are readily seen on red blood cells (RBC) treated with bromelain, or other proteolytic enzymes1. DeHeer and Edgington2 have recently described similar PFC in NZB mice.
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References
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CUNNINGHAM, A. Active suppressor mechanism maintaining tolerance to some self components. Nature 254, 143–144 (1975). https://doi.org/10.1038/254143a0
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DOI: https://doi.org/10.1038/254143a0
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