Abstract
RELEASING factors1 and other brain peptides2 have been the subject of extensive studies and the high sensitivity of modern measurement techniques has led to the discovery, in various tissues3,4 and in the nervous system5–9, of new, unpredicted locations for otherwise well known peptides. Evidence for the presence in the vertebrate nervous system of a hitherto undescribed brain gastrin immunoassayable peptide (BGP) is presented here.
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References
Bloom, F. E., Neurosci. Res. Prog. Bull., 10, 147–251 (1972).
Sano, I., Int. Rev. Neurobiol., 12, 235–263 (1970).
Dubois, M. P., Proc. natn. Acad. Sci. U.S.A., 72, 1340–1344 (1975).
Raikklin, N. T., Kvetnog, I. M., and Tolkachev, V. N., Nature, 255, 344–345 (1975).
Stumpf, W. E., and Grant, L. D., Science, 186, 1137–1138 (1974).
Daul, C. B., Heath, R. G., and Garey, R. E., Neuropharmacology, 14, 75–80 (1975).
Takahashi, T., Konishi, S., Powell, D., Leeman, S. E., and Otsuka, M., Brain Res., 73, 59–60 (1974).
Winokur, A., and Utiger, R. D., Science, 185, 265–267 (1974).
Brownstein, M., Arimura, A., Sato, H., Schally, A. V., and Kizer, J. S., Endocrinology, 96, 1456–1461 (1975).
Lowry, O. H., Roseborough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).
Lotstra, F., Van Der Loo, W., and Gepts, W., Diabetologia, 10, 291–302 (1974).
Herbert, V., Lon, K. S., Gottlieb, C. W., and Bleicher, S. J., J. clin. Endocr., 25, 1375–1384 (1965).
McGuigan, J. E., and Trudeau, W. L., Gastroenterology, 58, 139–150 (1970).
Schrumpf, E., and Sand, T., Scand. J. Gastroent., 7, 683–687 (1972).
Stadil, F., and Rehfeld, J., Scand. J. Gastroent., 8, 101–112 (1973).
Creutzfeldt, W., Arnold, R., Creutzfeldt, C., Feurle, G., and Ketterer, H., Eur. J. clin. Invest., 1, 461–479 (1971).
Berson, S., and Yalow, R. S., Gastroenterology, 60, 215–222 (1971).
Rehfeld, J. F., Stadil, F., and Rubin, B., Scand. J. clin. Lab. Invest., 30, 221–232 (1972)
Feldman, H., Rodbard, D., in Principles of Competitive Protein-binding Assays (edit. by Odell, W. D., and Daughaday, W. H.), 158–203 (Lippincott, Oxford, 1971).
Yalow, R. S., and Berson, S. A., Gastroenterology, 60, 203–215 (1971).
Anastasi, A., Erspamer, V., and Endean, R., Experientia, 23, 699–700 (1967).
Pearse, A. G. E., and Polak, J. M., Gut, 12, 783–788 (1971).
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VANDERHAEGHEN, J., SIGNEAU, J. & GEPTS, W. New peptide in the vertebrate CNS reacting with antigastrin antibodies. Nature 257, 604–605 (1975). https://doi.org/10.1038/257604a0
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DOI: https://doi.org/10.1038/257604a0
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