Abstract
ATTEMPTS to treat the mucopolysaccharidoses with infusions of normal plasma or leukocytes have produced mixed results; some workers1–3 reported little or no positive effect, while others4–6 noted both clinical and biochemical changes after treatment. Among the more obvious reasons for these conflicting findings are differences in the responsiveness to treatment of genetically distinct forms of the disorders7, in the volumes of plasma administered and in the activities of the corrective factors in the plasma.
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DEAN, M., MUIR, H., BENSON, P. et al. Increased breakdown of glycosaminoglycans and appearance of corrective enzyme after skin transplants in Hunter syndrome. Nature 257, 609–612 (1975). https://doi.org/10.1038/257609a0
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DOI: https://doi.org/10.1038/257609a0
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