Abstract
IMMUNOGLOBULINS (Igs) are present on the surface of murine bone-marrow derived (B) lymphocytes1–3. Combination of the membrane Ig and a specific antigen, together with the arrival of a signal from thymus-derived (T) lymphocytes induces B cells to divide and differentiate into antibody secreting plasma cells4. To understand the mechanism of that induction, it is necessary to know how Ig is attached to the cell surface.
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MELCHER, U., EIDELS, L. & UHR, J. Are immunoglobulins integral membrane proteins?. Nature 258, 434–435 (1975). https://doi.org/10.1038/258434a0
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DOI: https://doi.org/10.1038/258434a0
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