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Disruption of brain stimulation-induced feeding by dopamine receptor blockade

Nature volume 258, pages 750–751 (1975)Cite this article

Abstract

IT is well established that electrical stimulation of the lateral hypothalamus can be used to elicit a variety of biologically significant behaviour1,2. For many years, this behaviour was usually attributed to the artificial activation of neural systems which control consumatory responses, but this interpretation has been called into question3. The criticism arises in part from behavioural experiments in which stimulation-induced feeding and drinking were shown to differ from their natural counterparts in a number of important respects4,5, and also from neuro-pharmacological studies (ref. 6 and A.G.P. and H. C. Fibiger, unpublished) showing that food deprivation and brain stimulation-induced feeding or drinking were differentially affected by destruction of catecholamine (CA) systems in the brain. These latter results clearly implicated brain CAs in a stimulation-induced behaviour and as such emphasise the parallels between electrically-induced behaviour and stereotypies which accompany high doses of amphetamine7.

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References

  1. Mogensen, G. J., and Huang, Y. H., Prog. Neurobiol., 1, 55 (1973).

    Google Scholar 

  2. Roberts, W. W., in The Neural Control of Behavior, (edit. by Whalen, R. E., Thompson, R. F., Vergeano, M., and Weinberg, N. M.), 175 (Academic, New York, 1970).

    Book  Google Scholar 

  3. Valenstein, E. S., Cox, V. C., and Kakolewski, J. W., Psychol. Rev., 77, 16 (1970).

    Article  CAS  Google Scholar 

  4. Valenstein, E. S., Cox, V. C., and Kakolewski, J. W., Physiol. Behav., 3, 969 (1968).

    Article  Google Scholar 

  5. Valenstein, E. S., Kakolewski, J. W., and Cox, V. C., Comm. Behav. Biol., 2, 227 (1968).

    Google Scholar 

  6. Phillips, A. G., and Fibiger, H. C., Behav. Biol., 8, 749 (1973).

    Article  Google Scholar 

  7. Randrup, A., and Munkvad, I., in Amphetamines and Related Compounds (edit. by Costa, E. and Garattini, S.), 695 (Raven, New York, 1970).

    Google Scholar 

  8. Carr, L. A., and Moore, K. E., Science, 164, 322 (1969).

    Article  ADS  CAS  Google Scholar 

  9. Glowinski, J., and Baldessarini, R. J., J. Pharmac. Rev., 18, 1201 (1966).

    CAS  Google Scholar 

  10. Von Voitlander, P. F., and Moore, K. E., J. Pharmac. exp. Ther., 184, 542 (1973).

    Google Scholar 

  11. Creese, I., and Iversen, S. D., Brain Res., 83, 419 (1975).

    Article  CAS  Google Scholar 

  12. Price, M. T. C., and Fibiger, H. C., Eur. J. Pharmac., 29, 248 (1974).

    Article  Google Scholar 

  13. Ernst, A. M., and Smelik, P., Experientia, 22, 837 (1966).

    Article  CAS  Google Scholar 

  14. Anden, N. E., Butcher, S. G., Corrodi, H., Fuxe, K., and Ungerstedt, V., Eur. J. Pharmac., 11, 303 (1970).

    Article  CAS  Google Scholar 

  15. Zis, A. P., and Fibiger, H. C., Psychopharmacology, Berl., 43, 63 (1975).

    Article  CAS  Google Scholar 

  16. Ungerstedt, U., Acta physiol. scand., suppl., 367, 95 (1971).

    Article  CAS  Google Scholar 

  17. Fibiger, H. C., Zis, A. P., and McGeer, E. G., Brain Res., 55, 135 (1973).

    Article  CAS  Google Scholar 

  18. Marshall, J. F., and Teitelbaum, P., Brain Res., 55, 229 (1973).

    Article  CAS  Google Scholar 

  19. Antelman, S. M., and Szechtman, H., Science, 189, 731 (1975).

    Article  ADS  CAS  Google Scholar 

  20. Matthysse, S., in The Neurosciences: Third Study Program (edit. by Schmitt, F. O., and Worden, F. G.), 733 (MIT, Cambridge, 1974).

    Google Scholar 

  21. Valenstein, E. S., in Psychopathology of Human Adaptation (edit. by Serban, G., and Mason, J. W.), (Plenum, New York, in the press).

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Authors and Affiliations

  1. Department of Psychology, University of British Columbia, Vancouver, V6T 1W5, Canada

    ANTHONY G. PHILLIPS & ROY S. NIKAIDO

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  1. ANTHONY G. PHILLIPS
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  2. ROY S. NIKAIDO
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PHILLIPS, A., NIKAIDO, R. Disruption of brain stimulation-induced feeding by dopamine receptor blockade. Nature 258, 750–751 (1975). https://doi.org/10.1038/258750a0

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