Abstract
THE distribution of genotypes q2aa+2qpaA+p2AA, commonly called the Hardy–Weinberg law, has been recognised at least since 1908. It gives the frequencies of genotypes in a randomly mating population with respect to a single locus maintaining two alleles a and A with respective frequencies q and p. A generalisation given in 1922 by Wright and discussed in his book1 gives the distribution 
where F, the “fixation index” is the correlation between pairs of gametes uniting to form zygotes.
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References
Wright, S., Evolution and the Genetics of Populations, 2, 174 (University of Chicago Press, Chicago, 1969).
Fisher, R. A., Trans. R. Soc. Edinb., 52, 399–433 (1918).
Malécot, G., thesis, Univ. Paris (1939).
Malécot, G., C.r. hebd. Séanc. Acad. Sci. Paris, 226, 1682–1683 (1948).
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STARK, A. Generalisation of the Hardy–Weinberg law. Nature 259, 44 (1976). https://doi.org/10.1038/259044a0
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DOI: https://doi.org/10.1038/259044a0
