Abstract
BIOLOGICAL effects attributed to vitamin E include the maintenance of cell membrane integrity, inhibition of enzyme-dependent lipid peroxidation, participation in oxidative phosphorylation, and a general, non-enzymatic antioxidant effect1. In spite of these observations, the physiological function of the vitamin remains obscure. Natural deficiency in man has been invoked in the pathogenesis of several disorders, with convincing evidence limited to a specific type of haemolytic anaemia2. Therapeutically, vitamin E has its advocates in treatment of peripheral vascular and thromboembolic disease, although documentation for its efficacy is meagre3. Although it is considered non-toxic4, little is known about adverse effects of excessive dietary vitamin E.
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MOROZ, L., GILMORE, N. Inhibition of plasmin-mediated fibrinolysis by vitamin E. Nature 259, 235–237 (1976). https://doi.org/10.1038/259235a0
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DOI: https://doi.org/10.1038/259235a0
