Abstract
DESTRUCTION of antibody-coated mammalian target cells by normal human lymphocytes demonstrated by release of 51Cr-chromate is a phenomenon characterised by its rapidity of action and by the very small amounts of antibody required. It seems unlikely that such a mechanism destroys solely mammalian target cells, and possibly it has a role in immunity to parasitic infections. Butterworth et al.1 demonstrated that normal human blood cells destroy schistosomula coated with antibody from infected patients.
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References
Butterworth, A. E., Sturrock, R. F., Houba, V., and Rees, P. H., Nature, 252, 503 (1974).
Baker, J. R., Green, S. M., Chaloner, L. A., and Gaborak, M., Parasitology, 65, 251 (1972).
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MKWANANZI, J., FRANKS, D. & BAKER, J. Cytotoxicity of antibody-coated trypanosomes by normal human lymphoid cells. Nature 259, 403–404 (1976). https://doi.org/10.1038/259403a0
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DOI: https://doi.org/10.1038/259403a0
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