Abstract
WE have characterised two forms of deoxythymidine kinase (TK) using antisera prepared against the enzyme partially purified from human colonic mucosa. One of these forms is associated with rapidly proliferating lower colonic crypt cells and the other, with non-dividing surface cells. Antibody to the latter cross reacted with several tumours and placental extracts but not with phytohaemagglutinin (PHA)-stimulated or leukaemic lymphocytes. This cross reactivity of surface cells and colonic tumours supports the concept that surface cells rather than crypt cells are the site of origin of colonic cancer1,2.
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SALSER, J., BALIS, M. Foetal thymidine kinase in tumours and colonic flat mucosa of man. Nature 260, 261–263 (1976). https://doi.org/10.1038/260261a0
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DOI: https://doi.org/10.1038/260261a0
