Abstract
EUKARYOTIC RNA polymerases were isolated as large multimeric protein complexes containing two high molecular weight subunits and a collection of smaller polypeptide chains1–3. This structural complexity suggests a multifunctional system, organised around a core enzyme combined with specificity determinants and possibly other proteins involved in regulation of chromatin activity. The purpose of this report is to describe the association of a ribonuclease H activity with yeast RNA polymerase A. This nuclease activity, which specifically degrades RNA–DNA hybrids, is inseparable from the polymerase by various fractionation procedures.
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HUET, J., WYERS, F., BUHLER, JM. et al. Association of RNase H activity with yeast RNA polymerase A. Nature 261, 431–433 (1976). https://doi.org/10.1038/261431a0
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DOI: https://doi.org/10.1038/261431a0
