Abstract
THE therapeutic use of inhibitors of DNA synthesis as antiviral agents is hindered by their toxicity to dividing cells, which precludes the administration of effective doses. Consequently, although these drugs are very active in inhibiting virus replication in vitro, most of them are ineffective in vivo1,2.
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BALBONI, P., MINIA, A., GROSSI, M. et al. Activity of albumin conjugates of 5-fluorodeoxyuridine and cytosine arabinoside on poxviruses as a lysosomotropic approach to antiviral chemotherapy. Nature 264, 181–183 (1976). https://doi.org/10.1038/264181a0
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DOI: https://doi.org/10.1038/264181a0
