Abstract
WE have described a glycoprotein isolated from various mitochondria1, which binds Ca2+ with a dissociation constant of the same order of magnitude as the Km for Ca2+ transport2,3. This and other observations, including the effects of known Ca2+ transport inhibitors4,5 suggest that the protein is involved in the carrier mechanism for the transport of calcium in mitochondria. We have concluded that even passive efflux of Ca2+ from mitochondria requires the glycoprotein to be associated with the membrane6, and we consider this to be strong evidence that the passage of Ca2+ across the mitochondrial membrane requires the mediation of a transport system including the glycoprotein. We have sought to confirm these conclusions by immunological methods.
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References
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PANFILI, E., SANDRI, G., SOTTOCASA, G. et al. Specific inhibition of mitochondrial Ca2+ transport by antibodies directed to the Ca2+ -binding glycoprotein. Nature 264, 185–186 (1976). https://doi.org/10.1038/264185a0
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DOI: https://doi.org/10.1038/264185a0
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