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Hyperplastic nodules after portacaval anastomosis in rats

Nature volume 264, pages 440–442 (1976)Cite this article

Abstract

FOCAL proliferative or hyper-plastic regions of liver cells are readily recognised in human liver diseases1,2 and there is a possibility that some types of hyperplastic nodules are important for the development of liver cancer3. The case for the precancerous nature of hyperplastic nodules however, rests entirely on data derived from chemical hepatocar-cinogenesis and it is striking that toxic chemicals which are not known to lead to cancer do not induce hyperplastic nodules, whereas almost all hepatic carcinogens do give rise to nodules4. It seems of interest therefore to report the regular development of hyperplastic nodules in rats subjected to portacaval anastomosis without the addition of a known carcinogen to the diet or drinking water.

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Authors and Affiliations

  1. Department of Histopathology, Royal Postgraduate Medical School, DuCune Road, London, W12 0HS, UK

    K. WEINBREN & S. L. A. WASHINGTON

Authors
  1. K. WEINBREN
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  2. S. L. A. WASHINGTON
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WEINBREN, K., WASHINGTON, S. Hyperplastic nodules after portacaval anastomosis in rats. Nature 264, 440–442 (1976). https://doi.org/10.1038/264440a0

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