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Radiation-induced nondisjunction in oocytes of aged mice

Nature volume 265, pages 186–187 (1977)Cite this article

Abstract

SOME human epidemiological studies1–4 suggest that there may be an association between nondisjunction and preconception exposure to abdominal X rays in women. This response to radiation appears to increase with age2,4. To test this hypothesis, experimental evidence was sought by examining second metaphase chromosomes of cultured oocytes of mice. In the previous experiment5, abnormal segregation was induced in young mice, aged 3–6 months, by exposing them to a low dose of whole body gamma irradiation from a 137Cs source. We have now found that radiosensitivity increases with age.

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Authors and Affiliations

  1. Department of Pediatrics and Regional Cytogenetics Laboratory, McMaster University, Hamilton, Ontario, L8S 4J9, Canada

    IRENE A. UCHIDA & C. P. VIOLA FREEMAN

Authors
  1. IRENE A. UCHIDA
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  2. C. P. VIOLA FREEMAN
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UCHIDA, I., FREEMAN, C. Radiation-induced nondisjunction in oocytes of aged mice. Nature 265, 186–187 (1977). https://doi.org/10.1038/265186a0

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