Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Agrocin 84 is a 6-N-phosphoramidate of an adenine nucleotide analogue

Abstract

WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a ‘fraudulent’ member (structure I) of the hitherto unreported 6-N-phosphoramidate series of adenine nucleotides (structure II), of which 6-N-AMP (II, R=H) is the first member.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kerr, A., and Htay, Khin, Physiol. Pl. Path., 4, 37–44 (1974).

    Article  CAS  Google Scholar 

  2. Roberts, W. P., and Kerr, A., Physiol. Pl. Path., 4, 81–92 (1974).

    Article  CAS  Google Scholar 

  3. Stonier, T., J. Bact., 79, 889–898 (1960).

    CAS  PubMed  Google Scholar 

  4. Heip, J., Chatterjee, G. C., Vandekerckhove, J., Van Montague, M., and Schell, J., Arch. Int. Physiol. Biochim., 83, 974–976 (1975).

    CAS  PubMed  Google Scholar 

  5. Casini, G., and Goodman, L., J. Am. chem. Soc., 86, 1427–1431 (1964).

    Article  CAS  Google Scholar 

  6. Martinez, A. P., Lee, W. W., and Goodman, L., J. org. Chem., 31, 3263–3267 (1966).

    Article  CAS  Google Scholar 

  7. Ralph, R. K., and Khorana, H. G., J. Am. chem. Soc., 83, 2926–2934 (1961).

    Article  CAS  Google Scholar 

  8. Schweizer, M. P., McGrath, K., and Baczynski, L., Biochem. biophys. Res. Commun., 40, 1046–1052 (1970).

    Article  CAS  Google Scholar 

  9. Bredereck, H., and Martini, A., Chem. Ber., 80, 401–405 (1947).

    Article  CAS  Google Scholar 

  10. Tener, G. M., J. Am. chem. Soc., 83, 159–168 (1961).

    Article  CAS  Google Scholar 

  11. Reeves, P., The Bacteriocins, Molecular Biology and Biophysics, 11, 113 (Chapman and Hall, 1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ROBERTS, W., TATE, M. & KERR, A. Agrocin 84 is a 6-N-phosphoramidate of an adenine nucleotide analogue. Nature 265, 379–381 (1977). https://doi.org/10.1038/265379a0

Download citation

  • Received:

  • Accepted:

  • Issue date:

  • DOI: https://doi.org/10.1038/265379a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing