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Developmentally regulated lectin in neonatal rat brain

Nature volume 266, pages 367–369 (1977)Cite this article

Abstract

WE report the identification of a developmentally regulated agglutinin of erythrocytes present in neonatal rat brain. Specific inhibition by a number of saccharides with a galactose configuration suggest that multivalent carbohydrate-binding proteins, ‘endogenous brain lectins’, may be responsible for the observed agglutination activity. We are presently investigating the functional role of this lectin-like activity in brain, since molecules with similar carbohydrate-binding properties seem likely to mediate intercellular recognition and adhesion in certain lower eukaryotic organisms.

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Authors and Affiliations

  1. Langley Porter Neuropsychiatric Research Institute and Department of Pharmacology, University of California School of Medicine, San Francisco, California, 94143

    DAVID L. SIMPSON, DONALD R. THORNE & HORACE H. LOH

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  1. DAVID L. SIMPSON
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  2. DONALD R. THORNE
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SIMPSON, D., THORNE, D. & LOH, H. Developmentally regulated lectin in neonatal rat brain. Nature 266, 367–369 (1977). https://doi.org/10.1038/266367a0

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