Abstract
SINCE its original development by Jerne1, the haemolytic plaque assay has increased our understanding of antibody formation to a wide variety of antigens, including proteins, lipopolysaccharides, and simple haptens2. We have now developed an assay to detect plaque forming cells (PFC) making anti-nucleoside antibodies. Previously we reported the suppression of circulating antibody to DNA determinants by nucleoside-IgG conjugates3,4. Here we show that BALB/c mice can be rendered tolerant in terms of both direct and indirect anti-nucleoside antibody forming cells and that the state of tolerance is nucleoside-specific at the cellular level.
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STOLLAR, B., BOREL, Y. Nucleoside-specific tolerance suppresses anti-nucleoside antibody forming cells. Nature 267, 158–160 (1977). https://doi.org/10.1038/267158a0
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DOI: https://doi.org/10.1038/267158a0
