Abstract
THE best characterised properties of human interferon, its antiviral (AV) and cell multiplication inhibitory (CMI) activities, are controlled, in an unexplained manner, by genes on chromosomes 21 (refs 1–4; 14–16). Human and animal interferons have various immunosuppressive effects5–10, among them the inhibition in vitro of DNA synthesis in activated lymphocytes11. Using mitogen- and antigen-stimulated lymphocytes from normal subjects (disomic 21) and others with Down's syndrome (trisomic 21), we have found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons. We suggest that this property is also regulated by genes on chromosome 21.
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CUPPLES, C., TAN, Y. Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome. Nature 267, 165–167 (1977). https://doi.org/10.1038/267165a0
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DOI: https://doi.org/10.1038/267165a0
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