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Transmembrane channel formation in rhodopsin-containing bilayer membranes

Nature volume 267, pages 221–225 (1977)Cite this article

Abstract

Rhodopsin has been incorporated into planar lipid bilayer membranes. The effect of light is to increase the bilayer permeability in a pattern consistent with the formation of a transmembrane channel of about 10 Å diameter. A model of visual excitation based on a light-activated and voltage-sensitive channel is presented.

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References

  1. Hecht, S., Schlaer, S. & Pirenne, M. H. J. gen. Physiol. 25, 819–840 (1942).

    Article  CAS  Google Scholar 

  2. Hagins, W. A. A. Rev. Biophys. Bioengng 1, 131–158 (1972).

    Article  CAS  Google Scholar 

  3. Montal, M. & Korenbrot, J. I. in The Enzymes of Biological Membranes 4 (ed. Martonosi, A.) 365–405 (Plenum, New York, 1976).

    Book  Google Scholar 

  4. Wald, G. Nature 219, 800–807 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Hagins, W. A. Cold Spring Harb. Symp. quant. Biol. 30, 403–418 (1965).

    Article  CAS  Google Scholar 

  6. Hagins, W. A., Penn, R. D. & Yoshikami, S. Biophys. J. 10, 380–412 (1970).

    Article  CAS  Google Scholar 

  7. Millecchia, R. & Mauro, A. J. gen. Physiol. 54, 331–351 (1969).

    Article  CAS  Google Scholar 

  8. Wald, G., Brown, P. K. & Gibbons, I. R. J. Opt. Soc. Am. 53, 20–35 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Montal, M. & Korenbrot, J. I. Nature 246, 219–221 (1973).

    Article  ADS  CAS  Google Scholar 

  10. Montal, M. in Molecular Aspects of Membrane Phenomena (eds Kaback, H. R., Radda, G. K., Neurath, H., Wiley, W. R. & Schwyzer, R.) 316–338 (Springer-Verlag, New York, Berlin and Heidelberg, 1975).

    Book  Google Scholar 

  11. Darszon, A. & Montal, M. in Mitochondria-Bioenergetics, Biogenesis and Membrane Structure (eds Packer, L. & Gomez-Puyou, A.) 389–401 (Academic, New York, 1976).

    Google Scholar 

  12. Montal, M., Darszon, A., Korenbrot, J. I. & Trissl, H. W. V Intern. Biophys. Cong. IUPAB-Abstract, 177 (1975).

  13. Montal, M. in Perspectives in Membrane Biology (eds Estrada-O., S., Gitler, C.) 591–622 (Academic, New York, 1974).

    Google Scholar 

  14. Montal, M. Biochem. Soc. Trans. 4, 560–561 (1976).

    Article  CAS  Google Scholar 

  15. Trurnit, H. J. J. Colloid. Sci. 15, 1–13 (1960).

    Article  CAS  Google Scholar 

  16. Hubbard, R., Brown, P. K. & Bownds, D. Meth. Enzym. 18, 615–653 (1971).

    Article  Google Scholar 

  17. Ehrenstein, G., Lecar, H. & Nossal, R. J. gen. Physiol. 55, 119–133 (1970).

    Article  CAS  Google Scholar 

  18. Hladky, S. B., Gordon, L. G. M. & Haydon, D. A. A. Rev. Phys. Chem. 25, 11–38 (1974).

    Article  ADS  CAS  Google Scholar 

  19. Benzanilla, F. & Armstrong, C. M. J. gen. Physiol. 60, 588–608 (1972).

    Article  Google Scholar 

  20. Downer, N. W. & Englander, S. W. Nature 254, 625–627 (1975).

    Article  ADS  CAS  Google Scholar 

  21. Osborne, H. B. FEBS Lett. 67, 23–27 (1976).

    Article  CAS  Google Scholar 

  22. Robinson, G. W. Vision Res. 15, 35–48 (1975).

    Article  CAS  Google Scholar 

  23. Poo, M. & Cone, R. A. Nature 247, 438–441 (1974).

    Article  ADS  CAS  Google Scholar 

  24. Trissl, H. W., Darszon, A. & Montal, M. Proc. natn. Acad. Sci. U.S.A. 74, 207–210 (1977).

    Article  ADS  CAS  Google Scholar 

  25. Armstrong, C. R. Q. Rev. Biophys. 7, 179–210 (1975).

    Article  Google Scholar 

  26. Bownds, D., Gordon-Walker, A., Gaide-Huguenin, A. C. & Robinson, W. J. gen. Physiol. 58, 225–237 (1971).

    Article  CAS  Google Scholar 

  27. Ostwald, T. J. & Heller, J. Biochemistry 11, 4679–4686 (1972).

    Article  CAS  Google Scholar 

  28. Hodgkin, A. L. The Conduction of the Nervous Impulse (Liverpool University Press, Liverpool, 1963).

    Google Scholar 

  29. Montal, M. Meth. Enzym. 32 B, 545–554 (1974).

    Article  CAS  Google Scholar 

  30. Bamberg, E. & Läuger, P. Biochim. biophys. Acta 367, 127–133 (1974).

    Article  CAS  Google Scholar 

  31. McConnell, D. G. J. Cell Biol. 27, 459–473 (1965).

    Article  CAS  Google Scholar 

  32. Heller, J. Biochemistry 7, 2906–2913 (1968).

    Article  CAS  Google Scholar 

  33. Feldberg, N. T. Invest. Ophthalmol. 13, 155–157 (1974).

    Google Scholar 

  34. Kagawa, Y. & Racker, E. J. biol. Chem. 246, 5477–5487 (1971).

    CAS  Google Scholar 

  35. Racker, E. Biochem. biophys. res. Commun. 55, 224–230 (1973).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. M. Montal, A. Darszon & H. W. Trissl

    Present address: Department of Physics and Biology, University of California, San Diego, La Jolla, California, 92093

Authors and Affiliations

  1. Departamento de Bioquímica, Centre de Investigación y de Estudios Avanzados del Institute Politécnico National, México, 14, D.F.

    M. Montal, A. Darszon & H. W. Trissl

Authors
  1. M. Montal
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  2. A. Darszon
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  3. H. W. Trissl
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Montal, M., Darszon, A. & Trissl, H. Transmembrane channel formation in rhodopsin-containing bilayer membranes. Nature 267, 221–225 (1977). https://doi.org/10.1038/267221a0

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