Abstract
INDIRECT evidence suggests that Ca2+ is the mediator of the effects of acetylcholine and cholecystokinin-pancreozymin in pancreatic acinar cells. Sustained stimulation-evoked acinar fluid and enzyme secretion depends on extracellular Ca2+ (refs 1,2), stimulation causes uptake of 45Ca2+ from the extracellular fluid3 as well as release of 45Ca2+ from prelabelled glands with a dose–response curve very similar to stimulation-evoked membrane depolarisation and enzyme secretion4 and the Ca2+ ionophore A23187 induces enzyme secretion5 and membrane depolarisation6. We have examined directly the bioelectrical effects of iontophoretic application of Ca2+ from intracellular microelectrodes in a mammalian gland cell preparation.
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References
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IWATSUKI, N., PETERSEN, O. Acetylcholine-like effects of intracellular calcium application in pancreatic acinar cells. Nature 268, 147–149 (1977). https://doi.org/10.1038/268147a0
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DOI: https://doi.org/10.1038/268147a0
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