Abstract
THE sodium pump can catalyse several modes of cation exchange (for example Na:K, Na:Na, and K:K), which have been characterised mainly in human red blood cells1–3, squid giant axon4–6, and frog skeletal muscle7–9. In all three tissues it seems that intracellular ADP levels determine the extent to which the pump can engage in Na:Na exchange2,6,9,10. Yet, despite its obvious kinetic implications, the basic question of how the ‘normal’ Na:K exchange is affected by the appearance of ADP-induced Na:Na exchange, has not been answered. Here we present evidence that, in frog skeletal muscle, elevated intracellular ADP levels have little effect on pre-existing electrogenic Na:K exchange, but cause Na:Na exchange to appear in addition to ongoing Na:K exchange.
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KENNEDY, B., DE WEER, P. Relationship between Na:K and Na:Na exchange by the sodium pump of skeletal muscle. Nature 268, 165–167 (1977). https://doi.org/10.1038/268165a0
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DOI: https://doi.org/10.1038/268165a0
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